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Semaglutide is the GLP-1 receptor agonist that changed the metabolic research landscape. It mimics the body’s natural satiety hormone with a 7-day half-life — compared to minutes for endogenous GLP-1 — making it the most pharmacokinetically distinctive compound in metabolic peptide research. If you’re studying glucose regulation, appetite signalling, or metabolic pathways, this is the compound. True North Peptides supplies semaglutide at ≥99% purity in 5mg lyophilised vials. For research use only.
What Is Semaglutide?
Semaglutide is a GLP-1 receptor agonist — a synthetic version of the hormone your gut releases after eating to signal fullness, trigger insulin release, and suppress glucagon. Its C18 fatty acid modification allows it to bind to albumin in the bloodstream, extending its half-life from minutes (natural GLP-1) to approximately 7 days. This is why it became the backbone of the most significant metabolic research in the past decade.
What Researchers Are Studying It For
Three main areas: glucose regulation, appetite and weight control, and cardiovascular metabolic effects. On the glucose side, it stimulates insulin secretion only when blood glucose is elevated — so there’s a built-in safety mechanism. On the weight side, GLP-1 receptors in the hypothalamus and brainstem directly reduce appetite signals and slow gastric emptying. Clinical research has documented some of the most substantial weight reduction outcomes ever recorded for any investigational metabolic compound.
5mg vs 10mg — Which Vial?
Same compound, same purity. The 5mg vial (TNP-SEMA-05) suits standard research protocols or initial studies. The 10mg vial (TNP-SEMA-10) is the better choice for longitudinal protocols, larger study designs, or researchers who want batch-matched consistency across multiple experimental sessions.
Storage & Handling
Store lyophilised semaglutide at −20°C. Reconstitute with bacteriostatic water using gentle swirling — never shake. Store reconstituted solution at 2–8°C.
Product Specifications
Compound: Semaglutide (GLP-1 receptor agonist) | CAS: 910463-68-2 | Molecular Weight: 4,113.58 g/mol | Form: Lyophilised powder | Vial Size: 5mg | Purity: ≥99% | Storage: −20°C dry; 2–8°C post-reconstitution.
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