NAD+ 500mg

NAD+ 500mg — Ultra-Purity Research Grade

What Is NAD+?

Nicotinamide Adenine Dinucleotide (NAD+) is a dinucleotide coenzyme present in every cell of the human body. It is a critical component of cellular respiration — serving as an electron carrier in the mitochondrial oxidative phosphorylation chain — and plays a central role in over 500 enzymatic reactions. Beyond energy metabolism, NAD+ is the essential substrate for sirtuins (SIRT1–SIRT7), a family of proteins with profound influence over DNA repair, inflammation, metabolism, and biological ageing.

NAD+ levels decline with age, with metabolic stress, and with alcohol consumption and poor sleep — driving much of the interest in NAD+ repletion strategies in both clinical and biohacking contexts.

X-Fuel NAD+ is supplied at 500mg per vial, lyophilised to ultra-purity research grade — the highest-concentration single-vial format available.

Why the Community Uses It

NAD+ has moved from niche longevity supplement to mainstream biohacking staple, featured prominently in research by institutions including Harvard Medical School and Stanford. Community use centres on:

Cellular Energy & Fatigue

NAD+ sits at the core of ATP production. Users report increased energy, reduced fatigue, and improved mental clarity — particularly those running aggressive training or sleep-compromised schedules.

Sirtuin Activation & Longevity

Sirtuins require NAD+ to function. SIRT1 and SIRT3 in particular have been the focus of extensive longevity research — with associations to autophagy, mitochondrial biogenesis, and metabolic regulation.

DNA Repair via PARP Enzymes

PARP enzymes (poly ADP-ribose polymerases), which consume NAD+ to facilitate DNA repair, are increasingly studied in the context of cellular ageing and cancer biology. Maintaining adequate NAD+ pools supports PARP function.

Cognitive Function

NAD+ and its role in neuronal NAD+ pools has attracted interest in cognitive performance communities — particularly around brain fog, reaction time, and neuroinflammation.

Athletic Recovery

The NAD+ and exercise connection is well-documented: exercise consumes NAD+ through increased mitochondrial activity, and depleted NAD+ pools are theorised to contribute to diminished recovery capacity.

Injectable vs. Oral NAD+

Oral NAD+ supplements (NMN, NR, niacinamide) rely on conversion pathways and have variable bioavailability. Direct injectable NAD+ bypasses the GI tract entirely — delivering the coenzyme directly into circulation. This is the format used in clinical NAD+ IV infusion settings and is what X-Fuel’s 500mg vial is designed for.

Reconstitution & Storage

Reconstitute with sterile or bacteriostatic water. NAD+ is sensitive to heat and light — store unreconstituted vials refrigerated at 2–8°C. Reconstituted solution should be used promptly or within 24 hours if refrigerated. Protect from UV light at all stages.

Storage Information

NAD+ is heat and light sensitive. Store lyophilised vial refrigerated at 2–8°C away from light. Reconstituted solution should be used within 24 hours. Do not freeze.

Usage & Reconstitution

Reconstitute with sterile or bacteriostatic water. Due to its vasodilatory effects, intravenous NAD+ is typically administered slowly. Subcutaneous and intramuscular routes are also researched. Flush sensation during administration is commonly reported.