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KPV is a three-amino acid fragment derived from alpha-MSH — stripped down to just the anti-inflammatory component, without the pigmentation effects. It directly inhibits NF-κB, one of the master switches for inflammatory gene expression, making it one of the most targeted anti-inflammatory peptides available for research. Stacks directly with BPC-157, TB-500, and GHK-Cu in our KLOW blend. True North Peptides supplies KPV at ≥99% purity in 10mg lyophilised vials. For research use only.
What Is KPV?
KPV (Lysine-Proline-Valine) is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone (α-MSH). When researchers isolated what α-MSH was actually doing on the anti-inflammatory side, KPV is what they found. It keeps the powerful NF-κB inhibition and cytokine suppression, but drops the melanotropic effects entirely — making it a cleaner research tool for studying inflammation without the confounding variables.
What Researchers Are Studying It For
KPV’s primary mechanism is NF-κB inhibition — suppressing the master regulator of inflammatory gene expression. In practical terms, research shows it reduces TNF-α, IL-1β, and IL-6. It’s been studied heavily for gastrointestinal mucosal repair, particularly in colitis models where nanoparticle-delivered KPV significantly reduced mucosal inflammation markers. It also shows up in wound healing research for its ability to create an anti-inflammatory environment that lets tissue repair happen faster.
Why It’s In The KLOW Blend
Most peptide repair protocols focus on tissue growth and angiogenesis — and miss the inflammation piece. Chronic inflammation is what turns an acute injury into a long-term problem. KPV handles that side of the equation alongside GHK-Cu, BPC-157, and TB-500 in the KLOW blend. All four address different stages of the repair cascade simultaneously.
Storage & Handling
Store lyophilised KPV at −20°C. After reconstitution with bacteriostatic water, refrigerate at 2–8°C and use within 4 weeks.
Product Specifications
Peptide Sequence: Lys-Pro-Val | Molecular Weight: 342.44 g/mol | Form: Lyophilised powder | Vial Size: 10mg | Purity: ≥99% | Storage: −20°C dry; 2–8°C post-reconstitution.
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