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Melanotan-2 is a cyclic analogue of alpha-MSH engineered for metabolic stability and potent melanocortin receptor activation. It activates MC1R (melanogenesis) and MC4R (sexual function, appetite regulation) with a much longer biological half-life than the native hormone. If you’re researching the melanocortin system — pigmentation pathways, sexual function, or hypothalamic appetite control — MT-2 is the primary tool. True North Peptides supplies Melanotan-2 at ≥99% purity in 10mg lyophilised vials. For research use only.
Melanotan-2 is a synthetic cyclic analogue of alpha-melanocyte-stimulating hormone (α-MSH), developed by researchers at the University of Arizona. The key structural difference from linear α-MSH: the cyclic configuration and D-amino acid substitutions make it highly resistant to enzymatic degradation, giving it a dramatically extended biological half-life. The result is a more potent and longer-lasting melanocortin receptor agonist — one that researchers can use to study melanocortin pathways more effectively than with the native peptide.
MC1R — Melanogenesis Research
MC1R is expressed on melanocytes and drives eumelanin (dark pigment) synthesis in response to UV exposure. Melanotan-2’s potent MC1R agonism has been studied for its ability to stimulate melanogenesis both in cell culture and animal models. Research has examined its potential role in photoprotective pathways — the idea that stimulating melanin production could reduce UV-induced DNA damage in skin.
MC4R — Sexual Function and Appetite Research
MC4R is where Melanotan-2’s research profile gets broader. MC4R is expressed throughout the CNS — particularly in hypothalamic and limbic regions — and mediates sexual arousal, erectile function, and energy balance. MT-2’s high affinity for MC4R has made it a key research tool in studying melanocortin-mediated sexual function. It also produces anorectic effects through hypothalamic MC4R activation, which is why it appears in body composition research as well.
Melanotan-1 vs Melanotan-2
Melanotan-1 (afamelanotide) is a linear α-MSH analogue selective for MC1R — primarily studied for melanogenesis and photoprotection research. Melanotan-2 is the cyclic version with broader activity across MC1R and MC4R. MT-2’s added MC4R agonism extends its research applications well beyond pigmentation into sexual health and appetite regulation.
Storage & Handling
Store lyophilised Melanotan-2 at −20°C in a dry, light-protected environment. Reconstitute with bacteriostatic water, gentle swirling. Refrigerate at 2–8°C post-reconstitution, use within 4 weeks.
Product Specifications
Peptide: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ | CAS: 121062-08-6 | Molecular Weight: 1,024.18 g/mol | Form: Lyophilised powder | Vial Size: 10mg | Purity: ≥99% | Storage: −20°C dry; 2–8°C post-reconstitution.
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