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CJC-1295 is a GHRH analogue engineered for an exceptionally long half-life — days, not minutes. It uses a Drug Affinity Complex (DAC) to bind irreversibly to albumin in the bloodstream, creating sustained GH-releasing hormone receptor stimulation and continuous pulsatile GH secretion. If tesamorelin is the standard GHRH research tool, CJC-1295 DAC is the long-duration variant for studies requiring sustained GH axis activation over extended timeframes. True North Peptides supplies CJC-1295 at ≥99% purity in 5mg lyophilised vials. For research use only.
What Is CJC-1295?
CJC-1295 is a synthetic analogue of growth hormone-releasing hormone (GHRH) incorporating a Drug Affinity Complex (DAC) — a maleimide linker at the C-terminus that allows it to bind covalently and irreversibly to cysteine-34 on albumin. Once albumin-bound, CJC-1295 circulates with albumin’s half-life rather than its own, extending its GH-stimulating activity from minutes (native GHRH) to approximately 6–8 days. This makes it one of the longest-acting GHRH analogues available for research.
The DAC Mechanism — Why It Changes Everything
Most peptides are degraded within minutes to hours. CJC-1295’s DAC technology solves this by hitching the peptide to albumin — the most abundant protein in plasma. The result is a sustained GHRH signal at the pituitary over days, producing continuous stimulation of the GHRH receptor (GHRHR) and ongoing pulsatile GH secretion. For research requiring sustained GH axis activation — without repeated dosing — CJC-1295 DAC provides a fundamentally different research tool than shorter-acting GHRH analogues like tesamorelin.
GH Axis Research — Sustained vs Pulsatile
Native GH secretion is pulsatile — the pituitary releases GH in bursts, primarily during sleep. CJC-1295 DAC maintains continuous GHRHR stimulation, which produces ongoing GH pulsatility from the pituitary rather than a flat, sustained GH elevation. This is important: research distinguishes between pulsatile GH (which has different downstream effects on IGF-1 and body composition than continuous GH elevation). CJC-1295 DAC sustains the stimulus, not the GH itself — the pituitary still controls the pulse pattern.
CJC-1295 vs Tesamorelin
Both are GHRH receptor agonists. Tesamorelin has a half-life of hours and is studied for more controlled, shorter-duration GH axis activation. CJC-1295 DAC has a half-life of days due to albumin binding — making it the choice for research examining sustained GH axis stimulation over extended periods. They’re different tools for different research questions: tesamorelin for precision, CJC-1295 for duration.
Stacking With Ipamorelin
CJC-1295 (GHRHR agonist) and ipamorelin (GHSR-1a agonist) are among the most commonly combined GH secretagogue research tools because they stimulate GH release through completely different receptor pathways. CJC-1295 acts on the GHRH receptor; ipamorelin acts on the ghrelin receptor. Co-administration in animal models has shown synergistic GH release significantly greater than either compound alone — making this one of the most studied combination protocols in GH axis research.
Storage & Handling
Store lyophilised CJC-1295 at −20°C. Reconstitute with bacteriostatic water, gentle swirling. Refrigerate at 2–8°C post-reconstitution, use within 4–6 weeks. Avoid freeze-thaw cycles.
Product Specifications
Compound: CJC-1295 with DAC (GHRH analogue, albumin-binding) | Form: Lyophilised powder | Vial Size: 5mg | Purity: ≥99% | Storage: −20°C dry; 2–8°C post-reconstitution.
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