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GHK-Cu is a copper-binding tripeptide naturally present in human plasma — and it declines with age just like NAD+. When it’s abundant, it drives collagen synthesis, wound healing, and angiogenesis. What makes it genuinely remarkable is the scope: research shows GHK-Cu influences the expression of over 4,000 human genes, including many associated with ageing reversal in skin tissue models. True North Peptides supplies GHK-Cu at ≥99% purity in 50mg lyophilised vials. For research use only.
What Is GHK-Cu?
GHK-Cu (Glycyl-L-Histidyl-L-Lysine:Copper) is a tripeptide-copper complex found naturally in human plasma, saliva, and urine. In young adults it circulates at around 200ng/ml — and drops significantly as you age. Its copper-chelating structure lets it interact with a wide range of biological systems, and genome-wide analysis has shown it influences the expression of over 4,000 human genes. That’s not a typo — over 4,000, including genes governing collagen metabolism, DNA repair, inflammation, and cellular survival.
Collagen, Elastin, and Skin Matrix Research
GHK-Cu is one of the most studied compounds for stimulating collagen type I, III, and IV synthesis — the structural proteins that keep skin, tendons, and connective tissue intact. Fibroblast models show significant upregulation of collagen gene expression. It also drives elastin and glycosaminoglycan production. For researchers studying tissue engineering, dermal biology, or connective tissue repair, GHK-Cu is foundational.
Anti-Ageing Gene Expression Research
What separates GHK-Cu from most peptides is the breadth of its gene-modulating effects. Genome-wide analysis has identified it as capable of reversing gene expression patterns associated with ageing in skin tissue — turning down pro-ageing genes and turning up repair and survival pathways. It’s the most broad-spectrum longevity research peptide in the catalogue.
Why It’s The Lead Compound In KLOW
GHK-Cu makes up 50mg of the 80mg KLOW blend — the highest proportion — because it provides the broadest gene-level foundation for the blend’s tissue repair focus. BPC-157, TB-500, and KPV each contribute specific pathway targeting, but GHK-Cu does the heavy systemic lifting.
Product Specifications
Peptide: Gly-His-Lys:Cu²⁺ | CAS: 49557-75-7 | Molecular Weight: 409.91 g/mol | Form: Lyophilised powder | Vial Size: 50mg | Purity: ≥99% | Storage: −20°C dry; 2–8°C post-reconstitution.
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