Ipamorelin

Ipamorelin is a third-generation growth hormone secretagogue — a synthetic pentapeptide that activates the GHSR-1a (ghrelin receptor) at the pituitary to stimulate GH release. It was specifically designed to solve a problem with earlier GHRPs: they worked for GH release, but they also raised cortisol, prolactin, and ACTH. Ipamorelin was engineered to separate the GH stimulus from those off-target effects — and it succeeded. At effective research concentrations, cortisol and prolactin elevations are negligible.

Pulsatile GH — Why It Matters

Your pituitary naturally releases GH in pulses — not as a continuous stream. This pulsatile pattern is important because the downstream effects of GH on IGF-1, body composition, and cellular repair are regulated by this rhythm. Direct GH administration (somatropin) gives you a sustained, non-pulsatile GH profile. Ipamorelin triggers GH release in a pattern that closely mimics natural pulsatile secretion — which is why it’s a preferred tool for studying the GH axis in its natural physiological context.

Ipamorelin vs Tesamorelin

Both stimulate pituitary GH release, but through different receptors. Ipamorelin acts on GHSR-1a (the ghrelin receptor). Tesamorelin acts on GHRHR (the GHRH receptor). They’re the two most common GH secretagogue research tools, and many advanced protocols run them together — stimulating both GH release pathways simultaneously for a more complete GH axis investigation.

Storage & Handling

Store lyophilised ipamorelin at −20°C. Reconstitute with bacteriostatic water, gentle swirling. Refrigerate at 2–8°C post-reconstitution, use within 4–6 weeks.

Product Specifications

Peptide: Aib-His-D-2-Nal-D-Phe-Lys-NH₂ | CAS: 170851-70-4 | Molecular Weight: 711.85 g/mol | Form: Lyophilised powder | Vial Size: 10mg | Purity: ≥99% | Storage: −20°C dry; 2–8°C post-reconstitution.