NAD+

What Is NAD+?

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme present in every single cell in your body — and it’s one of the most important molecules in biology. It’s the electron carrier that drives the mitochondrial electron transport chain (where most of your cellular energy is made). It’s the substrate that sirtuins — your longevity-regulating genes — require to function. And it’s what PARP enzymes consume to repair broken DNA. The decline of NAD+ with age is now considered a central driver of the ageing process across multiple research frameworks.

Sirtuins — Your Longevity Switch

SIRT1 through SIRT7 are the sirtuin family — NAD+-dependent enzymes that regulate mitochondrial biogenesis, inflammation, circadian rhythm, and cellular stress response. They can’t function without NAD+. When NAD+ drops with age, sirtuin activity drops with it. Research into NAD+ repletion is largely about restoring the fuel that keeps these longevity-regulating enzymes operational.

NAD+ vs NMN vs NR — What’s The Difference?

NMN and NR are precursors — your cells convert them to NAD+ through enzymatic pathways. NAD+ is the end product. For research designs where you want to control exactly how much NAD+ is available at the cellular level — without the variable of precursor conversion efficiency — using NAD+ directly eliminates a confounding step. Both approaches are studied; the right choice depends on your research question.

Storage & Handling

NAD+ is sensitive to light and moisture. Store lyophilised NAD+ at −20°C in a sealed, light-protected container. Use reconstituted solutions promptly. Do not subject to freeze-thaw cycles.

Product Specifications

Compound: Nicotinamide Adenine Dinucleotide (NAD+) | CAS: 53-84-9 | Molecular Weight: 663.43 g/mol | Form: Lyophilised powder | Vial Size: 500mg | Purity: Research-grade | Storage: −20°C dry, protect from light.